2025 began with Catholics around the world uniting in prayer for Pope Francis’ health as he entered the hospital on Feb. 14. He was admitted to Gemelli Hospital in Rome for a respiratory infection that progressed to bilateral pneumonia, requiring a prolonged hospitalization that lasted almost six weeks.

Soon after, on March 29, the pontiff was readmitted into the hospital with difficulty breathing. On April 21, the day after Easter, Pope Francis passed away at the age of 88 from a stroke, coma, and irreversible cardiovascular collapse, according to the death certificate published just over 12 hours after his death.

On April 26, more than 400,000 people filled St. Peter’s Square for the funeral of Pope Francis as the world said goodbye to the first Latin American pope who led the Catholic Church for 12 years. 

Then on May 7, 133 cardinal electors gathered from all corners of the globe in the Sistine Chapel for the start of the conclave to elect a new pope. After four ballots, Cardinal Robert Prevost was elected on May 8 as the 267th bishop of Rome and leader of the Catholic Church. He took the name Pope Leo XIV. A Chicago native, he became the first American pope in Church history.

Here are some of the most impactful images from the papal transition — beginning with Pope Francis’ last general audience before being admitted to the hospital, the start of the conclave, and the election of Pope Leo: 

This article was originally published by CNA.